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Wednesday, September 10, 2008



BME 500 Seminar Series

Histotripsy: Imaging Guided Ultrasound Therapy for Non-invasive Surgery


Zhen Xu, Ph.D.
Research Scientist, Therapeutic Ultrasound Group
Biomedical Engineering
University of Michigan

Wednesday, September 10, 2008, 3:30 - 4:30 PM
White Auditorium - Rm G906 Cooley Building


Histotripsy is a new non-invasive technique that mechanically fractionates and removes soft tissue using high intensity ultrasound pulses. This technique can be viewed as soft tissue lithotripsy, which gave rise to the name "histotripsy." Using focused ultrasound pulses, histotripsy produces a cluster of energetic microbubbles within a treatment region. These microbubbles, each similar in size to individual cells, function as "mini-scalpels" to mechanically fragment and subdivide cell and tissue structures. These acoustic mini-scalpels can be clearly visualized on clinical ultrasound imaging system, which are used to guide and monitor the histotripsy treatment. Histotripsy has potential for many clinical applications where non-invasive tissue removal is desired. We have been developing histotripsy for breaking down diseased clots (thrombolysis), removing unwanted tissue and tumors inside organs including prostate, kidneys, and breasts, and heart.