S P O T L I G H T


Shea Named Chair of U-M BME

August 25, 2014 Contact: Brandon Baier, 734-647-6109, bbaier@umich.edu

Ann Arbor, MI – Lonnie D. Shea has been named professor and chair of the University of Michigan Department of Biomedical Engineering (BME), effective September 1, 2014.

Shea, who earned his PhD from U-M in 1997, was recruited from Northwestern University’s Department of Chemical and Biological Engineering, where he has served on the faculty since 1999. He is an internationally recognized researcher at the interface of regenerative medicine, drug and gene delivery, and immune tolerance, whose focus is controlling the local microenvironment for directing tissue growth or regeneration. His projects include ovarian follicle maturation for treating infertility, islet transplantation for diabetes therapies, nerve regeneration for treating paralysis, autoimmune diseases and allogeneic cell transplantation, and cancer diagnostics. He is also developing and applying systems biology approaches to molecularly dissect tissue formation and identify key drivers of normal and abnormal growth.

Shea has received funding from the National Institutes of Health (NIH), National Science Foundation (NSF) and multiple foundations; has published more than 150 manuscripts on his research; and has numerous inventions to his credit, among them a cellular assay with which he can measure the activity of numerous transcription factors within the cell that reveal key signaling pathways as cells differentiate and develop in his customized 3D cultures.
In addition to his research and teaching responsibilities at Northwestern, Shea served as director of its NIH Biotechnology Training Grant and was a member of its Institute for BioNanotechnology in Medicine. He is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), a standing member of the Biomaterials and Bionterfaces study section at NIH, and a member of the editorial boards for Molecular Therapy, Biotechnology and Bioengineering, and Drug Delivery and Translational Research.

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N E W S


Engineers row in royal regatta

ROW BLUE! From July 2-6, a squad of Michigan rowers will represent the Block M on the River Thames, an hour west of London. Recent U-M BME grad Alex Crawford and six more of the other twelve U-M oarsmen competing are engineering majors! More than 100,000 spectators, including much of the Royal Family, will be in attendance. To read the full Michigan Engineering article see: http://umicheng.in/1iQLDL9

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Sept Article Named Paper of the Year

An article that BME Associate Professor David Sept authored with Ron Bose and other collaborators from Washington University in St. Louis was selected as a 2013 paper of the year in the Journal of Biological Chemistry.  It won in the signal transduction category for providing the first structural characterization of HER2-HER3 heterodimers used in cancer therapy. The paper is titled Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface. It can be accessed at www.jbc.org/site/bestoftheyear/.

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