Mohamed ElSayed Hamed ElSayed, Ph.D.

Associate Professor, Department of Biomedical Engineering & Macromolecular Science and Engineering Program

University of Michigan
1101 Beal Avenue
Lurie Biomedical Engineering Building, Room 2150
Ann Arbor, MI 48109

Phone: (734) 615-9404
Fax: (734) 647-4834
E-mail: melsayed@umich.edu


EDUCATION:

  • Postdoctoral Research Fellow, University of Washington, Department of Bioengineering, Seattle, WA, 11/2002 - 09/2006.
  • Ph.D. in Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD, 07/1999 - 07/2002.
  • M.S. in Pharmaceutics, University of Mississippi, School of Pharmacy, Oxford, MS, 08/1997 - 07/1999.
  • B.Sc. of Pharmacy & Pharmaceutical Chemistry, Cairo University, Faculty of Pharmacy, Cairo, Egypt, 08/1989 - 05/1994.

RESEARCH INTERESTS:

My research program focuses on the development of bio-inspired drug delivery systems that enhance the therapeutic activity of the incorporated drug molecules while eliminating or minimizing their potential side effects. We follow two parallel research tracks to achieve this goal. In Track I-Development of Targeted Therapeutic & Diagnostic Nano-Medicine (projects 1, 2, 3), we rationally design and synthesize novel polymeric carriers that can effectively exploit established transport mechanisms to permeate across the different epithelial and endothelial barriers encountered within the body to selectively shuttle their therapeutic cargo to the diseased tissues with cellular and sub-cellular accuracy. In Track II-Mechanistic Investigation of Cellular & Sub-Cellular Trafficking Pathways (projects 4, 5, 6), we aim to better understand the transport routes of small molecules, macromolecules, and polymeric drug delivery systems across epithelial/endothelial barriers and the mechanisms that govern their cellular uptake and subcellular trafficking under normal and pathological conditions. We utilize the knowledge acquired from investigations in both tracks to guide the design of the next generation of targeted therapies for early detection and treatment of life-threatening diseases. Our ultimate goal is to translate our research findings into diagnostic and therapeutic tools for early detection and treatment of life-threatening diseases with special emphasis on solid tumors (e.g. breast, prostate, hepatic, and head and neck cancer) and CNS disorders. Specific areas of research include:

  • Development of Targeted, Enzyme-Activated, Nano-Conjugates for Selective and Tunable Release of Chemotherapeutic Agents in Hepatic Cancer Cells.
  • Development of "Smart" Particles for Enhancing the Cytoplasmic Delivery of Therapeutic Nucleic Acids.
  • Development of Targeted Nano-Droplets for Ultrasound Imaging and Ablation of Prostate Cancer.
  • Innovative Strategies for Intratumoral Delivery of Particulate Carriers.
  • Development of a 3D In Vitro Model of the Blood-Brain Barrier in Layered Microfluidic Channels.
  • Engineering Pathogen-Mimetic Oral Drug Delivery Systems.

PROFESSIONAL EXPERIENCE:

  • Member, Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI, 09/2010 - Present.
  • Member, Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI, 06/2008 - Present.
  • Member of Advisory Committee, Michigan Post-baccalaureate Research Education Program (PREP), Ann Arbor, MI, 12/2007 - Present.
  • Member, UM Comprehensive Cancer Center, Molecular Therapeutics & Breast Oncology Programs, Ann Arbor, MI, 09/2007 - Present.
  • Member, Pharmaceutical Engineering Graduate Program, University of Michigan, Ann Arbor, MI, 01/2007 - Present.
  • Assistant Professor of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 11/2006 - Present.
  • Postdoctoral Research Fellow, University of Washington, Department of Bioengineering, Seattle, WA, 11/2002 - 09/2006.
  • Visiting Researcher, Guilford Pharmaceuticals Inc., Department of Exploratory Pharmaceutics, Baltimore, MD, 06/2000 - 08/2002.
  • Graduate Teaching Assistant, University of Maryland, Department of Pharmaceutical Sciences, Baltimore, MD, 08/1999 - 05/2000.
  • Visiting Researcher, University of Tennessee in Memphis, School of Biomedical Engineering, Circulatory Research Laboratory, Memphis, TN, 12/1998 - 07/1999.
  • Senior Pharmacist, United Pharmaceuticals, Inc., Jeddah, KSA, 06/1996 - 07/1997.
  • Graduate Teaching and Research Assistant, Al-Azhar University, Department of Pharmaceutics and Industrial Pharmacy, Assuit, Egypt, 10/1994 - 05/1996.

HONORS & AWARDS:

2013 Young Investigator Awardee, 2013 Frontiers in Bioengineering Workshop, Georgia Tech-Parker H. Petit Institute for Bioengineering & Bioscience, February 25-26, 2013, Atlanta, Georgia.
2011 Invited Speaker, 18th International Symposium on Microencapsulation, September 11-14, 2011, Antalya, Turkey.
2010 Invited Speaker, Special Session: "Nanomedicine Research Reports", 8th International Nanomedicine and Drug Delivery Symposium, October 3-5, 2010, Omaha, Nebraska.
2008-2011 Translational Research Partnership in Biomedical Engineering Award, Coulter Foundation, USA.
2008 Faculty Early Career Development Award (CAREER), National Science Foundation, USA.
2005-2008 The Susan G. Komen Breast Cancer Foundation, Postdoctoral Fellowship.
2005-2008 The U.S. Department of Defense-Multidisciplinary Postdoctoral Award in Breast Cancer Research.
2004-2006 The National Cancer Center, Postdoctoral Fellowship.
2002 Travel Award, 4th Intensive Course and Workshop on Cell Culture and Ex-Vivo Models for Drug Absorption and Delivery, Saarbrucken, Germany.
2001-2002 Academic Merit Award, University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD.
2001 Travel Award, 10th International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, Utah.
2000 Podium Presentation Award, 20th Annual Graduate Research Association of Students in Pharmaceutics Conference, Baltimore, MD.
2000 Poster Presentation Award, 22nd Annual Graduate Research Conference, University of Maryland Baltimore County, Baltimore, MD.
2000 Charles A. Stevens Memorial Award, 7th Annual Student Poster Night - Philadelphia Pharmaceutical Forum, Ambler, PA.
1999 Travel Award, 14th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, New Orleans, Louisiana.
1999 Podium Presentation Award, 2nd annual meeting of the American Association of Pharmaceutical Scientists-Southern Regional Discussion Group, Monroe, Louisiana.
1999 Travel Award, 2nd annual meeting of the American Association of Pharmaceutical Scientists-Southern Regional Discussion Group, Monroe, Louisiana.
1999 Membership of the Rho-Chi National Pharmacy Honor Society.

INVITED TALKS:

  1. University of Maryland, College of Pharmacy, April 30, 2014, Baltimore, MD. Title: TBD.

  2. 2nd Middle Eastern Conference on Biomedical Engineering, February 17-20, 2014, Doha, Qatar. Talk 1: Development of In Vitro Model of the Blood-Brain Barrier in Layered Microfluidic Channels. Talk 2: Developpment of Targeted, Enzyme-Activated, Nano-Conjugates for Hepatic Cancer Therapy.

  3. University of California-San Francisco, Graduate Programs in Pharmaceutical Sciences, Pharmacogenomics, and Bioengineering Seminar Series, October 22, 2013, San Francisco, CA. Title: TBD.

  4. International Conference and Exhibition on Biochemical & Molecular Engineering, October 7-9, 2013, San Antonio, Texas. Talk 1: Development of Enzyme-Activated Nano-Conjugates for Targeted Hepatic Cancer Therapy; Talk 2: Development of "Smart" Vectors for Enhanced Cytoplasmic Delivery of Therapeutic Nucleic Acids.

  5. University of Maryland, Institute of Bioscience & Biotechnology Research, April 15, 2013, College Park, Maryland. Title: TBD.

  6. 4th Kuwait International Pharmacy Conference, February 4-6, 2013, Kuwait City, Kuwait. Title: TBD.

  7. University of Utah, Department of Pharmaceutics & Pharmaceutical Chemistry and the Nanotechnology Training Program, November 5, 2012, Salt Lake City, Utah. Title: TBD.

  8. Controlled Release Society Education Workshop "Critical Appraisal of EPR Effect and Intratumoral Distribution of Nanomedicine", Montreal, Quebec, Canada, July 14, 2012. Title: Synergistic Effect of Therapeutic US on Intratumoral Delivery of Therapeutic Nanoparticles.

  9. University of Illinois-Urbana Champaign, Department of Materials Science and Engineering, Urbana Champaign, Illinois, April 23, 2012. Title: Development of Enzyme-Activated Nano-Conjugates for Hepatic Cancer Cell-Specific Delivery of Anticancer Drugs.

  10. Weill Cornell Medical College-Qatar, January 9, Doha, Qatar. Title: Development of Enzyme-Activated Nano-Conjugates for Targeted Hepatic Cancer Therapy.

  11. 14th International Union of Pure and Applied Chemistry Conference on Polymers and Organic Chemistry, January 6-9, 2012, Doha, Qatar. Title: Rational Design & Synthesis of "Intelligent" Star Polymers for Cytoplasmic Delivery of Therapeutic Nucleic Acids.

  12. 18th International Symposium on Microencapsulation, September 11-14, 2011, Antalya, Turkey. Title: Engineering Enzyme-Activated Nano-Conjugates for Cell-Specific Delivery and Release of Chemotherapeutic Agents.

  13. Upper Midwest Biomaterials Day, May 12-13, 2011, Ann Arbor, Michigan. Title: Rational Design and Synthesis of Enzyme-Sensitive Particles for Targeted Delivery of Anticancer Drugs.

  14. Biomedical Engineering Society Seminar, April 5, 2011, Ann Arbor, MI. Title: Development of Stimuli-Sensitive Carriers for Enhanced Cytoplasmic Delivery of Therapeutic Macromolecules.

  15. University of Michigan Urology Department, Ann Arbor, Michigan, March 7, 2011. Title: Development of Targeted Nanoparticles for Focal Prostate Cancer Therapy.

  16. 8th International Nanomedicine and Drug Delivery Symposium, Special Session: "Nanomedicine Research Reports", October 3-5, 2010, Omaha, Nebraska. Title: Design and Evaluation of "Smart" Degradable Particles for Effective Gene Silencing.

  17. University of Southern California, Department of Chemical Engineering and Material Sciences, September 9, 2010, Los Angeles, CA. Title: "Smart" Degradable Particles for Targeted Gene Silencing.

  18. University of Michigan, Michigan Nanotechnology Institute for Medicine and Biological Sciences, August 8, 2010, Ann Arbor, MI. Title: "Smart" Degradable Particles for Cytoplasmic Delivery of Nucleic Acids.

  19. Southern Methodist University, Chemistry Department, April 30, 2010, Dallas, TX. Title: "Intelligent" Particles for Cytoplasmic delivery of Therapeutic Nucleic Acids.

  20. University of Texas-Arlington, Department of Biomedical Engineering, April 29, 2010, Arlington, TX. Title: Synergistic Effect of Therapeutic Ultrasound on Particles Delivery into Solid Tumors.

  21. University of Illinois-Chicago, College of Pharmacy, Department of Pharmaceutical Sciences, April 26, 2010, Chicago, Illinois. Title: Synergistic Effect of Therapeutic Ultrasound on Particles Delivery into Solid Tumors.

  22. Ohio State University, Department of Biomedical Engineering, April 21, 2010, Columbus, OH. Title: "Intelligent" Particles for Effective Intracellular Delivery of Macromolecular Therapeutics.

  23. Misr International University, Faculty of Pharmacy, September 30, 2009, Cairo, Egypt. Title: In Vitro Evaluation of "Smart" Particles for Intracellular Drug Delivery.

  24. National Research Center, Division of Pharmaceutical and Medicinal Chemistry, September 29, 2009, Cairo, Egypt. Title: "Smart" Carriers for Delivery of Molecular Therapeutics.

  25. German University in Cairo, Faculty of Pharmacy and Biotechnology, September 28, 2009, Cairo, Egypt. Title: Development of "Smart" Particles for Delivery of Therapeutic Nucleic Acids.

  26. Imperial College, Department of Materials Science and Engineering, April 28, 2009, London, UK. Title: "Intelligent" Particles for Enhanced Intracellular Delivery of Therapeutic Nucleic Acids.

  27. Central Michigan University of Michigan, Department of Mathematics, April 9, 2009, Mount Pleasant, Michigan. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  28. University of Michigan, Department of Pharmaceutical Sciences, October 29, 2008, Ann Arbor, Michigan. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  29. The University of California-Irvine, The Henry Samueli School of Engineering, Department of Chemical Engineering & Material Science, April 4, 2006, Irvine, California. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  30. The University of Utah, College of Engineering, Department of Biomedical Engineering, March 30, 2006, Salt Lake City, Utah. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  31. The University of California-Davis, College of Engineering, Department of Biomedical Engineering, March 9, 2006, Davis, California. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  32. The University of Texas at Austin, College of Pharmacy, Department of Pharmaceutics, March 2, 2006, Austin, Texas. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  33. The University of Michigan, the College of Engineering-Department of Biomedical Engineering, and the School of Dentistry-Department of Biologic and Material Sciences, February 16, 2006, Ann Arbor, Michigan. Title: "Smart" Delivery Systems for Macromolecular Therapeutics.

  34. The University of California-Los Angeles, The Henry Samueli School of Engineering and Applied Science, Department of Bioengineering, January 30, 2006, Los Angeles, California. Title: Therapeutic and Diagnostic Applications of Novel "Smart" Nano-Polymers.

  35. The University of Iowa, College of Pharmacy, Division of Pharmaceutics, and the College of Engineering, Department of Biomedical Engineering, January 23, 2006, Iowa City, Iowa. Title: "Smart" Polymeric Carriers for Enhanced Trans-Epithelial and Endothelial Drug Transport, and Sub-Cellular Drug Targeting.

  36. The University of Kansas, School of Pharmacy, Department of Pharmaceutical Chemistry, November 14, 2005, Lawrence, Kansas. Title: Therapeutic and Diagnostic Applications of Novel "Smart" Nano-Polymers.

  37. The Cleveland Clinic Foundation, Lerner Research Institute, Department of Biomedical Engineering, November 3, 2005, Cleveland, Ohio. Title: "Smart" Nanomedicines: The Rise of a New Era of Polymer Therapeutics.

  38. University of Kentucky, College of Pharmacy, Department of Pharmaceutical Sciences, October 11, 2005, Lexington, Kentucky. Title: Therapeutic and Diagnostic Applications of Novel "Intelligent" Polymers.

  39. Purdue University, Departments of Industrial & Physical Pharmacy, and Biomedical Engineering, September 6, 2005, West Lafayette, Indiana. Title: "Intelligent" Polymeric Carriers for Enhanced Trans-Epithelial and Endothelial Drug Transport, and Sub-Cellular Drug Targeting.

  40. Nastech Pharmaceutical Company, Inc., R&D Department, December 8, 2004, Seattle, Washington. Title: Intelligent Polymers for Enhancing Intestinal Permeability, Microvascular Extravasation, and Intracellular Delivery of Therapeutic Molecules.

  41. University of Washington, School of Medicine, Division of Oncology, Tumor Vaccine Group, August 10, 2004, Seattle, Washington. Title: Development of Smart Polymeric Carriers for Enhanced Intracellular Delivery of Therapeutic Nucleic Acids.

  42. University of Maryland School of Pharmacy, Department of Pharmaceutical Sciences, Pharmacy Research Day, April 27, 2004, Baltimore, Maryland. Title: Postdoctoral training: Challenges and opportunities.

  43. Harvard Medical School and Shriners Burns Hospital, Center for Engineering in Medicine, January 23, 2002, Boston, Massachusetts. Title: Transepithelial and Endothelial Transport of Poly(amidoamine) Dendrimers.

  44. Harvard Medical School and Massachusetts General Hospital, Department of Pediatric Gastroenterology, January 22, 2002, Boston, Massachusetts. Title: Development and Evaluation of Dendritic Carriers for Oral Drug Delivery.

  45. Saarland University, Department of Biopharmaceutics and Pharmaceutical Technology, July 4, 2000, Saarbrucken, Germany. Title: Extravasation of Polyamdioamine Dendrimers across Microvascular Network Endothelium.


PROFESSIONAL MEMBERSHIPS:

  • The American Association of Pharmaceutical Scientists (1998-Present).
  • The American Chemical Society (2000-Present).
  • American Society for Engineering Education (2007-Present).
  • Biomedical Engineering Society (2009-Present).
  • The Controlled Release Society (1998-Present).
  • Materials Research Society (2009-Present).
  • The Rho-Chi National Pharmacy Honor Society (1999-Present).
  • The Society for Biomaterials (2002-Present).
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