Publications
SELECTED PUBLICATIONS IN BIOMEDICAL OPTICS
C.-W. Chang and M.-A. Mycek: Quantitative molecular imaging in living cells via fluorescence lifetime imaging microscopy The Annual Reviews of Fluorescence, (C. Geddes, Ed.) (in press, 2010).
C.-W. Chang and M.-A. Mycek: Precise fluorophore lifetime mapping in live-cell, multi-photon excitation microscopy Optics Express, Vol.18, No.8, pp.8688-8696 (2010).
M. Keller, R.H. Wilson, M.-A. Mycek, A. Mahadevan-Jansen: Monte Carlo model of spatially offset Raman spectroscopy for breast tumor margin analysis Applied Spectroscopy (in press, Vol.64, No.6, 2010).
M. Raghavan, N.D. Sahar, R.H. Wilson, M.-A. Mycek, N. Pleshko, D.H. Kohn, M.D. Morris: Quantitative polarized Raman spectroscopy in highly turbid bone tissue Journal of Biomedical Optics (in press, 2010).
M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek: Spectral areas and ratios classifier algorithm for pancreatic tissue classification using optical spectroscopy Journal of Biomedical Optics, Vol.15, No.1, 010514 (2010).
C.-W. Chang, M. Wu, S.D. Merajver, and M.-A. Mycek: Physiological fluorescence lifetime imaging microscopy improves Förster resonance energy transfer detection in living cells Journal of Biomedical Optics, Vol.14, No.6, 060502 (2009).
R.H. Wilson, M. Chandra, J. Scheiman, D. Simeone, B. McKenna, J. Purdy, and M.-A. Mycek: Optical spectroscopy detects histological hallmarks of pancreatic cancer Optics Express, Vol.17, No.20, pp.17502-17516 (2009).
D. Sud and M.-A. Mycek: Calibration and validation of an optical sensor for intracellular oxygen measurements Journal of Biomedical Optics, Vol.14, No.2, 020506 (2009).
D. Sud and M.-A. Mycek: Image restoration for fluorescence lifetime imaging microscopy (FLIM) Optics Express, Vol. 16, pp.19192-19200 (2008)
Z. Xu, M. Raghavan, T.L. Hall, M.-A. Mycek, J.B. Fowlkes, C.A. Cain: Evolution of bubble clouds produced in pulsed cavitational ultrasound therapy - histotripsy IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol.55, pp. 1122-1132 (2008).
M. Chandra, J. Scheiman, D. Heidt, D. Simeone, B. McKenna, and M.-A. Mycek: Probing pancreatic disease using tissue optical spectroscopy Journal of Biomedical Optics, Vol.12, 060501 (2007).
C.-W. Chang, D. Sud, and M.-A. Mycek: Fluorescence lifetime imaging microscopy in Methods in Cell Biology, (G. Sluder and D. Wolf, Eds.) Elsevier Inc., Vol.81, Ch. 24 (2007).
W. Zhong, M. Wu, C.-W. Chang, K.A. Merrick, S.D. Merajver, and M.-A. Mycek: Picosecond-resolution fluorescence lifetime imaging microscopy: a useful tool for sensing molecular interactions in vivo via FRET Optics Express, Vol. 15, pp. 18220 - 18235 (2007).
Z. Xu, M. Raghavan, T.L. Hall, C.-W. Chang, M.-A. Mycek, J.B. Fowlkes, C.A. Cain: High speed imaging of bubble clouds generated in pulsed ultrasound cavitational therapy - histotripsy IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 54, pp. 2091-2101 (2007).
G. Mehta, K. Mehta, D. Sud, J.W. Song, T. Bersano-Begey, N. Futai, Y.S. Heo, M.-A. Mycek, J.J. Linderman, S. Takayama: Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture Biomedical Microdevices, Vol.9, No.2, pp.123-134 (2007).
K. Vishwanath, W. Zhong, M. Close, and M.-A. Mycek: Fluorescence quenching by polystyrene microspheres in UV-visible and NIR tissue-simulating phantoms Optics Express, Vol.14, No.17, pp.7776-7788 (2006).
D. Sud, G. Mehta, K. Mehta, J. Linderman, S. Takayama, and M.-A. Mycek: Optical imaging in microfluidic bioreactors enables oxygen monitoring for continuous cell culture Journal of Biomedical Optics, Vol.11, 050504 (2006).
M. Chandra, K. Vishwanath, G.D. Fichter, E. Liao, S.J. Hollister, and M.-A. Mycek: Quantitative molecular sensing in biological tissues: an approach to non-invasive optical characterization Optics Express, Vol.14, No.13, pp.6157-6171 (2006).
D. Sud, W. Zhong, D.G. Beer, and M.-A. Mycek: Time-resolved optical imaging provides a molecular snapshot of altered metabolic function in living human cancer cell models Optics Express, Vol.14, No.10, pp.4412-4426 (2006).
S. Mioc and M.-A. Mycek: Selected laser-based therapies in otolaryngology in Bioengineering in Otolaryngology, (A.D. Meyers, Ed.) Otolaryngologic Clinics of North America, W.B. Saunders. Inc., Philadelphia, Vol.38, No.2, pp. 241-254 (2005).
K. Vishwanath and M.-A. Mycek: Time-resolved photon migration in bi-layered tissue models Optics Express, Vol.13, No.19, pp.7466-7482 (2005).
K. Vishwanath and M.-A. Mycek: Do fluorescence decays remitted from tissues accurately reflect intrinsic fluorophore lifetimes? Optics Letters, Vol.29, pp.1512-1514 (2004).
P.K. Urayama and M.-A. Mycek: Fluorescence lifetime imaging microscopy of endogenous biological fluorescence in Handbook of Biomedical Fluorescence, (M.-A. Mycek and B.W. Pogue, Eds.) Marcel-Dekker, Inc., New York, pp. 211-236 (2003).
M.-A. Mycek and B.W. Pogue, Eds.: Handbook of Biomedical Fluorescence Biomedical Optics Series, Marcel-Dekker, Inc., New York (2003).
P. Urayama, W. Zhong, J.A. Beamish, F.K. Minn, R.D. Sloboda, K.H. Dragnev, E. Dmitrovsky, and M.-A. Mycek: A UV-Visible-NIR fluorescence lifetime imaging microscope for laser-based biological sensing with picosecond resolution Applied Physics B: Lasers and Optics, Vol.76, pp.483-496 (2003). (Invited.)
W. Zhong, P. Urayama, M.-A. Mycek: Imaging fluorescence lifetime modulation of a ruthenium-based dye in living cells: the potential for oxygen sensing Journal of Physics D: Applied Physics, Vol.36, pp.1689-1695 (2003).
K. Vishwanath and M.-A. Mycek: Polystyrene microspheres in tissue-simulating phantoms can collisionally quench fluorescence Journal of Fluorescence, Vol.13, No.1, pp.105-108 (2003).
K. Vishwanath, B.W. Pogue, M.-A. Mycek: Quantitative fluorescence lifetime spectroscopy in turbid media: Comparison of theoretical, experimental, and computational methods Physics in Medicine and Biology, Vol.47, pp.3387-3405 (2002).
B.W. Pogue, J.D. Pitts, M.-A. Mycek, R.D. Sloboda, C. Wilmot, J.A. Brandsema, J.A. O'Hara: In vivo NADH fluorescence monitoring as an assay for cellular damage in photodynamic therapy Photochemistry and Photobiology, Vol.74, No.6, pp.817-824 (2001).
A. Sefkow, M. Bree, M.-A. Mycek: A method for measuring cellular optical absorption and scattering evaluated using dilute cell suspension phantoms Applied Spectroscopy, Vol.55, No.11, pp.1495-1501 (2001).
J.D. Pitts and M.-A. Mycek: Design and development of a rapid acquisition laser-based fluorometer with simultaneous spectral and temporal resolution Review of Scientific Instruments, Vol.72, No.7, pp.3061-3072 (2001).
J.D. Pitts, R.D. Sloboda, K.H. Dragnev, E. Dmitrovsky, M.-A. Mycek: Autofluorescence characteristics of immortalized and carcinogen-transformed human bronchial epithelial cells Journal of Biomedical Optics, Vol.6, No.1, pp.31-40 (2001).
B.W. Pogue, M.-A. Mycek, D. Harper: Image analysis for discrimination of cervical neoplasia in colposcopy Journal of Biomedical Optics, Vol.5, No.1, pp.72-82 (2000).
M.-A. Mycek, K.T. Schomacker, N.S. Nishioka: Colonic polyp differentiation using time-resolved autofluorescence spectroscopy Gastrointestinal Endoscopy, Vol.48, No.4, pp.390-394 (1998).
N.S. Nishioka, M.-A. Mycek: Initial experience with a real-time video processor for enhancing endoscopic image contrast Gastrointestinal Endoscopy, Vol.48, No.1, pp.62-66 (1998).
SELECTED PUBLICATIONS IN CONDENSED MATTER PHYSICS AND ULTRAFAST OPTICS
M.-A. Mycek, J.-Y. Bigot, I.E. Perakis, and D.S. Chemla: Measuring the ultrafast dynamics of Coulomb correlation effects: Dephasing in non-equilibrium Fermi seas Journal of the Optical Society of America B - Optical Physics, Vol.13, No.6, pp.1284-1290 (1996).
U. Siegner, S. Glutsch, S. Bar-Ad, M.-A. Mycek, P. Kner, D.S. Chemla: Coherent dynamics and dephasing of one-dimensional magnetoexcitons in GaAs Journal of the Optical Society of America B - Optical Physics, Vol.13, No.5, pp.969-976 (1996).
M.-A. Mycek, U. Siegner, S. Glutsch, and D.S. Chemla: Ultrafast spectroscopy of GaAs under magnetic field: Coulomb correlated magnetoexcitons in the 3D to 1D transition Journal of Physics and Chemistry of Solids, Vol.56, No.11, pp.1543-1547 (1995).
M.-A. Mycek, J.-Y. Bigot, I.E. Perakis, and D. S. Chemla: Ultrafast dynamics of Coulomb correlation effects in non-equilibrium Fermi seas Journal of Nonlinear Optical Physics and Materials, Vol.4, No.2, pp.497-510 (1995).
U. Siegner, M.-A. Mycek, S. Glutsch, and D.S. Chemla: Ultrafast nonlinear optical response of Fano resonances in GaAs under high magnetic field Physica Status Solidi B - Basic Research, Vol.188, No.1, pp.361-367 (1995).
U. Siegner, M.-A. Mycek, S. Glutsch, and D.S. Chemla: Quantum interference in the system of Lorentzian and Fano magnetoexciton resonances in GaAs Physical Review B - Condensed Matter, Vol.51, No.8, pp.4953-4961 (1995).
U. Siegner, M.-A. Mycek, S. Glutsch, and D.S. Chemla: Ultrafast coherent dynamics of Fano resonances in semiconductors Physical Review Letters, Vol.74, No.3, pp.470-473 (1995).
S. Glutsch, U. Siegner, M.-A. Mycek, and D.S. Chemla: Fano resonances due to coupled magnetoexciton and continuum states in bulk semiconductors Physical Review B - Condensed Matter, Vol.50, No.23, pp.17009-17017 (1994).
J.-Y. Bigot, M.-A. Mycek, S. Weiss, R.G. Ulbrich, and D.S. Chemla: Amplitude decay and instantaneous frequency dynamics of excitonic polarization in semiconductor quantum wells in Coherent Optical Interactions in Semiconductors, (R.T. Phillips, Ed.) Plenum Press, New York, pp.245-260 (1994).
M.-A. Mycek, U. Siegner, and D.S. Chemla: Ultrafast magnetoexciton dynamics in GaAs in Ultrafast Phenomena IX, (P.F. Barbara et al., Eds.) Springer Series in Chemical Physics, Vol.60, Springer, Berlin, pp.417-418 (1994).
D.S. Chemla, J.-Y. Bigot, M.-A. Mycek, S. Weiss, and W. Schaefer: Ultrafast phase dynamics of coherent emission from excitons in GaAs quantum wells Physical Review B - Condensed Matter, Vol.50, No.12, pp.8439-8453 (1994).
J.-Y. Bigot, M.-A. Mycek, S. Weiss, R.G. Ulbrich, and D.S. Chemla: Instantaneous frequency dynamics of coherent wave mixing in semiconductor quantum wells Physical Review Letters, Vol.70, No.21, pp.3307-3310 (1993).
S. Weiss, M.-A. Mycek, J.-Y. Bigot, S. Schmitt-Rink, and D.S. Chemla: Observation of many body effects in the femtosecond temporal profile of quasi-2D exciton free induction decay in Ultrafast Phenomena VIII, (J.-L. Martin et al., Eds.), Springer Verlag, p. 466 (1993).
S. Weiss, M.-A. Mycek, J.-Y. Bigot, S. Schmitt-Rink, and D.S. Chemla: Collective effects in excitonic free induction decay: do semiconductors and atoms emit coherent light in different ways? Physical Review Letters, Vol.69, No.18, pp.2685-2688 (1992).
M.-A. Mycek, S. Weiss, J.-Y. Bigot, S. Schmitt-Rink, D.S. Chemla, and W. Schaefer: Femtosecond time-resolved free-induction decay of room-temperature excitons in GaAs quantum wells Applied Physics Letters, Vol.60, No.21, pp.2666-2668 (1992).
A.D. Katnani, A. Knoll, and M.A. Mycek: Effects of environment and heat treatment on an oxygen plasma-treated polyimide surface and its adhesion to a chromium overcoat Journal of Adhesion Science and Technology, Vol.3, No.6, pp.441-453 (1989).