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Biomedical Imaging

Core Faculty


Charles A. Cain, Ph.D.
Founding Chair, Biomedical Engineering
Professor, Biomedical Engineering
Professor, Electrical Engineering & Computer Science
Richard A. Auhll Professor, Engineering

2121 Carl A. Gerstacker Building
2200 Bonisteel Boulevard
Ann Arbor, MI 48109-2099

Phone: (734) 764-9589
Fax: (734) 936-1905
Email: cain@eecs.umich.edu
Website: www.histotripsy.umich.edu


More Info: For the past five years, Professor Cain's research team has been developing a new technique called "Histotripsy" which is a non-invasive ultrasonic tissue fractionation approach for the treatment of benign disease and cancer. Histotripsy results in localized tissue removal with sharp boundaries, which they use to remove cardiac tissue in treatment of congenital heart disease. In bulk tissue, histotripsy produces mechanical fragmentation of tissue resulting in a liquefied core with very sharply demarcated boundaries. Histology demonstrates that treated tissue within the lesion is fragmented to subcelluar level surrounded by an almost imperceptibly narrow margin of cellular injury. Histotripsy has vast clinical applications where precise tissue ablation and removal are needed (e.g., tumor treatment).


Research Areas: Biomedical Imaging, Biomedical Ultrasonics and Image-Guided Therapy.


Cheri X. Deng, Ph.D.
Associate Professor, Biomedical Engineering

2111 Carl A. Gerstacker Building
2200 Bonisteel Boulevard
Ann Arbor, MI 48109-2099

Phone: (734) 936-2855
Email: cxdeng@umich.edu
Website: sitemaker.umich.edu/denglab


More Info: Professor Deng's lab focuses on research and development in the field of biomedical ultrasound. The objective of the lab is to obtain improved understanding of the processes and mechanism involved in ultrasound interaction with biological systems for the purpose of developing efficient techniques for diagnosis and treatment of human diseases. Specific research projects include ultrasound mediated drug and gene delivery for cancer treatment and gene therapy, high intensity focus ultrasound ablation of cardiac arrhythmias such as atrial fibrillation, as well as quantitative ultrasound imaging for improved pancreatic cancer detection.


Research Areas: Biomedical Imaging, Biomedical Ultrasonics and Image-Guided Therapy, Drug Delivery and Therapeutics.


Douglas C. Noll, Ph.D.
Chair, Biomedical Engineering
Ann and Robert H. Lurie Professor, Biomedical Engineering
Professor, Radiology
Co-Director, fMRI Center

1119 Carl A. Gerstacker Building
2200 Bonisteel Boulevard
Ann Arbor, MI 48109-2099

Phone: (734) 764-9194
Fax: (734) 936-4218
Email: dnoll@umich.edu
Website: www.bme.umich.edu/labs/dnoll/


More Info: Prof. Noll's group develops magnetic resonance imaging (MRI) technology for mapping the functional organization the human brain performing specific tasks (known as functional MRI or fMRI). The group's research is in two main areas: 1) understanding the neurovascular physiology associated with brain activity and quantifying the biophysical connection to the MR images and 2) development of image acquisition, image reconstruction, signal processing, and hardware approaches to provide high-speed and robust measurement of function over the entire brain. As part of Functional MRI Laboratory, this group collaborates with a broad range of neuroscientist to develop an understanding of the organization and functioning of the normal brain and to apply the technological advances to quantitative imaging of brain function in a variety of neurological and psychiatric disorders.


Research Areas: Biomedical Imaging, Functional and Molecular Imaging.


Zhen Xu, Ph.D.
Assistant Professor, Biomedical Engineering

2107 Carl A. Gerstacker Building
2200 Bonisteel Boulevard
Ann Arbor, MI 48109-2099

Phone: (734) 647-4961
Fax: (734) 939-1905
Email: zhenx@umich.edu
Website: www.bme.umich.edu/labs/xulab/


More Info: Dr. Xu's research group focuses on developing image-guided therapy for cardiovascular applications. Her lab has been developing non-invasive therapy methods to remove pathological blood clots, which are the key mechanism behind many cardiovascular diseases including stroke and deep vein thrombosis. This new method can locally destroy clot without any incision or catheter insertion, and has potential to greatly reduce the complications of current clot remove methods. Her lab is also working on non-invasive fetal therapy that may prevent certain congenital diseases from developing before birth.


Research Areas: Biomedical Imaging, Biomedical Ultrasonics and Image-Guided Therapy.



Jointly Appointed Faculty


Larry Antonuk, Ph.D.
Professor, Radiation Oncology
Professor, Biomedical Engineering

Argus Building 1
519 West William Street
Ann Arbor, MI 48103-4943

Phone: (734) 936-4312
Fax: (734) 936-2261
Email: antonuk@umich.edu
Website (Medical School Faculty Page): Click Here
Website (Lab Page): www-personal.umich.edu/~antonuk/


Research Areas: Biomedical Imaging.


James R. Baker, Jr., M.D.
Ruth Dow Doan Professor, Internal Medicine
Director, Biologic Nanotechnology Institute
Professor, Internal Medicine
Professor, Biomedical Engineering
Chief, Division of Allergy and Immunology

9220C MSRB III
1150 West Medical Center Drive
Ann Arbor, MI 48109-0644

Phone: (734) 647-2777
Fax: (734) 936-2990
Email: jbakerjr@umich.edu


Research Areas: Bio-Nanotechnology, Biomedical Computation and Modeling, Biomedical Imaging, Biomembranes, Drug Delivery and Therapeutics.


James Balter, Ph.D.
Professor, Radiation Oncology
Professor, Biomedical Engineering

B2C490 UH
1500 East Medical Center Drive
Ann Arbor, MI 48109-0010

Phone: (734) 936-4309
Fax: (734) 936-7859
Email: jbalter@umich.edu
Website: sitemaker.umich.edu/balterresearch/home


Research Areas: Biomedical Imaging, Biomedical Ultrasonics and Image-Guided Therapy, Functional and Molecular Imaging.


Omer Berenfeld, Ph.D.
Associate Professor, Internal Medicine
Associate Professor, Biomedical Engineering

026-229S NCRC
2800 Plymouth
Ann Arbor, MI 48109-2800

Phone: (734) 998-7560
Fax: (734) 998-7511
Email: oberen@umich.edu
Website: www.med.umich.edu/arrhythmia_research/faculty/berenfeld.htm


Research Areas: Biomedical Computation and Modeling, Biomedical Imaging, Biomedical Optics, Cardiac Arrhythmias.


Kristy K. Brock, Ph.D.
Associate Professor, Radiation Oncology
Associate Professor, Biomedical Engineering

B2C432 UH
1500 East Medical Center Drive
Ann Arbor, MI 48109-0010

Phone: (734) 936-4294
Fax: (734) 936-7859
Email: kkbrock@med.umich.edu


More Info: Research Interests 1. Biomechanical Model-Based Deformable Registration: In 2003, I developed a research program focused on the development of a novel deformable modeling technique using biomechanical models and finite element analysis, Morfeus. The technique, which is substantially different than the widely available deformable image registration algorithms that rely on image intensity, incorporates the biomechanical properties of tissues to model the complex interaction of neighboring tissues and tumors. The application has been tested and validated on a number of anatomical sites including head and neck, lung, breast, esophagus, liver, pancreas, stomach, cervix, prostate, and rectum. This has expanded to include modeling of tissue response to radiation, applications in small animals, and generation of 3D or 4D models from limited data. 2. Dose Reconstruction: The development of Morfeus, the biomechanical model-based deformable registration algorithm, has enabled investigations into the reconstruction of a more accurate calculation of the dose delivered to the tumor and surrounding normal tissue over the course of treatment. With the use of accurate deformable registration, the impact of breathing motion, tissue deformation, and tissue volume changes on the delivered dose has been investigated retrospectively to enable intelligent design of prospective clinical trials to adapt to these changes. 3. Correlative Pathology: The use of deformable registration to integrate multi-modality images has raised the question of which imaging modality, or combination correctly identifies the tumor boundary? I have developed a research program in correlative pathology (deformable registration between histology and in vivo images) to investigate this issue. To understand the changes in the material properties during fixation, I have also begun to research the application of magnetic resonance elastography (MRE). The MRE research has also enabled an additional research focus on small animal imaging and intervention to evaluate radiation and drug response, which will improve our understanding of these complex changes for applications in human clinical studies.


Research Areas: Biomedical Imaging.


Paul L. Carson, Ph.D.
Professor, Biomedical Engineering
BRS Collegiate Professor, Radiology
Associate Director, Basic Radiological Sciences Division

3218C Medical Science Building I, B Wing
1301 Catherine Street
Ann Arbor, MI 48109-5667

Phone: (734) 763-5884
Fax: (734) 764-8541
Email: pcarson@umich.edu
Website: Click Here


Research Areas: Bio-Nanotechnology, Biomedical Imaging, Biomedical Optics, Biomedical Ultrasonics and Image-Guided Therapy, Drug Delivery and Therapeutics, Functional and Molecular Imaging.


Timothy Chupp, Ph.D.
Professor, Physics
Professor, Biomedical Engineering

4241 Randall Lab
450 Church Street
Ann Arbor, MI 48109-1120

Phone: (734) 647-2514
Fax: (734) 763-9694
Email: chupp@umich.edu
Website: www.physics.lsa.umich.edu/chupp/


Research Areas: Biomedical Imaging, Functional and Molecular Imaging.


Jeffrey A. Fessler, Ph.D.
Professor, Biomedical Engineering
Professor, Electrical Engineering & Computer Science
Professor, Department of Radiology

4431 EECS
1301 Beal Street
Ann Arbor, MI 48109-2122

Phone: (734) 763-1434
Email: fessler@umich.edu
Website: www.eecs.umich.edu/~fessler


Research Areas: Biomedical Imaging, Image Reconstruction.


J. Brian Fowlkes, Ph.D.
Professor, Radiology
Professor, Biomedical Engineering

3226C Medical Science Building I, B Wing
1301 Catherine Street
Ann Arbor, MI 48109-5667

Phone: (734) 763-5882
Fax: (734) 764-8541
Email: fowlkes@umich.edu


Research Areas: Biomedical Imaging, Biomedical Ultrasonics and Image-Guided Therapy.


Craig J. Galban, Ph.D.
Assistant Professor, Radiology
Core Director, Center for Molecular Imaging
Research Investigator, Biomedical Engineering

AC51 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Phone: (734) 764-8726
Fax: (734) 615-1599
Email: cgalban@umich.edu


Research Areas: Biomedical Imaging, Functional and Molecular Imaging.


Luis Hernandez-Garcia, Ph.D.
Research Associate Professor, Biomedical Engineering
Research Associate Professor, Functional MRI Laboratory

1096 BIRB
2360 Bonisteel Blvd.
Ann Arbor, MI 48109-2108

Phone: (734) 763-9254
Fax: (734) 963-4128
Email: hernan@umich.edu
Website: www.eecs.umich.edu/~hernan


Research Areas: Biomedical Computation and Modeling, Biomedical Imaging, Functional and Molecular Imaging.


Alfred O. Hero, Ph.D.
Professor, Biomedical Engineering
Professor, Electrical Engineering & Computer Science
Professor, Statistics

4229 EECS
1301 Beal Street
Ann Arbor, MI 48109-2122

Phone: (734) 763-0564
Fax: (734) 763-8041
Email: hero@umich.edu
Website: www.eecs.umich.edu/~hero/


Research Areas: Biomedical Imaging, Functional and Molecular Imaging.


Kimberlee J. Kearfott, Sc.D.
Professor, Biomedical Engineering
Professor, Nuclear Engineering and Radiological Sciences
Adjunct Professor, Radiology

1943 Cooley Lab
2355 Bonisteel Boulevard
Ann Arbor, MI 48109-2104

Phone: (734) 763-9117
Fax: (734) 763-4540
Email: kearfott@umich.edu
Website: www-personal.umich.edu/~kearfott


Research Areas: Biomedical Computation and Modeling, Biomedical Imaging.


Jinsang Kim, Ph.D.
Associate Professor, Materials Science and Engineering
Associate Professor, Chemical Engineering
Associate Professor, Macromolecular Science and Engineering
Associate Professor, Biomedical Engineering

2098 H.H. Dow Building
2300 Hayward Street
Ann Arbor, MI 48109-2136

Phone: (734) 936-4681
Fax: (734) 763-4788
Email: jinsang@umich.edu
Website: msewww.engin.umich.edu/people/faculty/kim


Research Areas: Bio-Nanotechnology, Biomedical Imaging.


Kenneth M. Kozloff, Ph.D.
Assistant Professor, Orthopaedic Surgery
Assistant Professor, Biomedical Engineering

2015 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Phone: (734) 936-2158
Email: kenkoz@umich.edu
Website: www.umich.edu/~skeleton


Research Areas: Biomedical Imaging, Drug Delivery and Therapeutics, Functional and Molecular Imaging, Molecular and Cellular Biomechanics, Organ and Whole Body Biomechanics.


Christian M. Lastoskie, Ph.D.
Associate Professor, Biomedical Engineering
Associate Professor, Civil and Environmental Engineering

180 G.G. Brown
2350 Hayward Street
Ann Arbor, MI 48109-2125

Phone: (734) 647-7940
Fax: (734) 763-2275
Email: cmlasto@umich.edu
Website: www-personal.engin.umich.edu/~cmlasto


Research Areas: Biomaterials, Biomedical Imaging.


Parag G. Patil, M.D., Ph.D.
Assistant Professor, Neurosurgery
Assistant Professor, Biomedical Engineering

3446B Taubman Center
1500 East Medical Center Drive
Ann Arbor, MI 48109-5338

Phone: (734) 936-9579
Fax: (734) 936-9294
Email: pgpatil@umich.edu


Research Areas: Biomedical Computation and Modeling, Biomedical Imaging, Neural Engineering.


Thomas D. Wang, M.D., Ph.D.
Associate Professor, Internal Medicine
Associate Professor, Biomedical Engineering

1522 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109-2200

Phone: (734) 936-1228
Fax: (734) 647-7950
Email: thomaswa@umich.edu
Website: sitemaker.umich.edu/ntr/home
Website: sitemaker.umich.edu/betrnet


Research Areas: Biomedical Imaging, Biomedical Optics, Functional and Molecular Imaging.



Emeritus Faculty


Leslie W. Rogers, Ph.D.
Professor Emeritus, Biomedical Engineering
Professor Emeritus, Internal Medicine
Senior Research Scientist Emeritus, Internal Medicine

3480 Kresge Research Building III
204 Zina Pitcher Place
Ann Arbor, MI 48109-0552

Phone: (734) 763-3277
Fax: (734) 764-0288
Email: tnirps@umich.edu


Research Areas: Biomedical Imaging.